… Here, we summarize the pharmacologic therapies that have the potential to suppress
SARS-CoV-2-induced cytokine storms (Table 1). The medications that target the performance of …

… In this paper, we will elaborate the role of cytokine storm mediated by JAK-STAT pathway in
… baricitinib blocking SARS-CoV-2 entry into the target cells and controlling the cytokine storm, …

… pDCs are at the eye of the storm In severe COVID-19, macrophages induce cytokine storms,
… not directly infected by SARS-CoV-2, so how this cytokine storm is induced remains unclear. …

… In examining leukocyte and cytokine … cytokine responses lead to disease and/or organ
damage. By better understanding the mechanisms that drive the intensity of a cytokine storm, we …

… rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as
to … of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection. …

… -related cytokine storm is induced by a “spike protein-CD147-CyPA signaling axis”: Infection
of SARS-CoV-… Consequently, the MAPK pathway regulated the expression of cytokines and …

… -2 release histamine which increases IL-1 levels involved in cytokine storm and, … by
SARS-CoV-2 are involved in viral inflammation, contributing to the formation of the cytokine storm by …

… SARS-CoV-2 have a high cytokine profile similar to CS. Studies have reported the level of
inflammatory factors in patients with SARSCoV-2 during CS, cytokine … IL-6 in severe SARSCoV…

… that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor
to cytokine storm … the pathogenesis of cytokine storm caused by SARS-CoV-2 and provide a …

… Nevertheless, IL-6-blocking … , as IL-6 is not solely responsible for the cytokine storm in
COVID-19 because it still remains unclear whether elevated IL-6 in viral infections, and SARS-CoV-…