Decreased neutralization of SARS-CoV-2 global variants by therapeutic anti-spike protein monoclonal antibodies

T Tada, BM Dcosta, H Zhou, A Vaill, W Kazmierski… - BioRxiv, 2021 - biorxiv.org
… analyzed neutralizing titers of REGN10933 and REGN10987 for viruses with the SARS-CoV
REGN10933 maintains neutralizing activity against B.1.1.7 but has lost neutralizing activity …

Neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants induced by natural infection or vaccination: a systematic …

X Chen, Z Chen, AS Azman, R Sun, W Lu… - Clinical Infectious …, 2022 - academic.oup.com
… mutations in spike protein that were associated with decreased neutralizing potency to evade
humoral immunity. However, the decrease in neutralizing potency was more obvious in B.…

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

D Planas, D Veyer, A Baidaliuk, I Staropoli… - Nature, 2021 - nature.com
… With the Delta variant, neutralization titres were significantly decreased by four- to sixfold
when compared to the Alpha and D614G strains, respectively (Extended Data Fig. 7a). This …

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

T Tada, H Zhou, BM Dcosta, MI Samanovic… - …, 2022 - thelancet.com
… The decrease in neutralizing titres … the neutralizing antibody response to SARS-CoV-2
variants upon vaccination. To determine whether previous infection would increase neutralizing

Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

X Deng, MA Garcia-Knight, MM Khalid, V Servellita… - Cell, 2021 - cell.com
… Antibody neutralization assays revealed 4.0- to 6.7-fold and 2.0-fold decreases in neutralizing
… in California exhibiting decreased antibody neutralization warrants further investigation. …

SARSCoV‐2 variants and vulnerability at the global level

VP Chavda, AB Patel… - Journal of medical …, 2022 - Wiley Online Library
… Numerous variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
evasive immunological features, decrease neutralization using antibodies from vaccinated …

Neutralizing antibodies against SARS-CoV-2 variants after infection and vaccination

VV Edara, WH Hudson, X Xie, R Ahmed, MS Suthar - Jama, 2021 - jamanetwork.com
… The fourth variant, N501Y SARS-CoV-2 virus, containing a … Live-virus focus reduction
neutralization tests (FRNTs) were … the reciprocal dilution of serum that neutralizes 50% of the input …

Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

S Marot, I Malet, V Leducq, K Zafilaza, D Sterlin… - Nature …, 2021 - nature.com
SARS-CoV-2 antibody levels decrease from 8 weeks after the onset of symptoms and that
serum samples from 33% of SARS-CoV-2-infected patients display no neutralizingSARS-CoV-…

Comparison of neutralizing antibody titers elicited by mRNA and adenoviral vector vaccine against SARS-CoV-2 variants

T Tada, H Zhou, MI Samanovic, BM Dcosta… - BioRxiv, 2021 - biorxiv.org
… variants but significantly decreased neutralization by those … , and neutralized the variants
with titers that were decreased by … by variant shows the decreased neutralizing titers against the …

The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

K Murano, Y Guo, H Siomi - Biochemical Society Transactions, 2021 - portlandpress.com
… of human origin that neutralize the SARS-CoV-2 infection have been … Emerging variants of
SARS-CoV-2 present new challenges for … Here, we review the problems faced by neutralizing