Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a Phase I, open-label, dose-escalating, randomized controlled study

SH Khoo, R Fitzgerald, T Fletcher… - Journal of …, 2021 - academic.oup.com
… In this trial (NCT04746183) we evaluated the safety and optimal dose of … safety and tolerability
of multiple ascending doses of molnupiravir in participants with PCR-confirmed SARS-CoV

Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59 years: report of the randomized, double-blind, and placebo-controlled …

Y Zhang, G Zeng, H Pan, C Li, B Kan, Y Hu, H Mao… - medrxiv, 2020 - medrxiv.org
safety of a SARS-CoV-2 inactivated vaccine (CoronaVac). … to evaluate the optimal dose,
immunogenicity and safety of the … 2 injections of the trial vaccine at a dose of 3 μg/0.5 mL or 6 μg …

… dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety …

MG Silva Borba, FF Almeida Val, VS Sampaio… - MedRxiv, 2020 - medrxiv.org
… Due to the impossibility of not using the drug recommended at the national … dosage of CQ
(12 g total dose over 10 days) in COVID-19 should not be recommended because of safety

Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1–2 …

PA Goepfert, B Fu, AL Chabanon… - The Lancet Infectious …, 2021 - thelancet.com
… being developed against SARS-CoV-2. We present interim safety and immunogenicity results
of the … candidate vaccine will focus on identifying the optimal antigen formulation and dose. …

Camostat mesylate against SARSCoV‐2 and COVID‐19—Rationale, dosing and safety

P Breining, AL Frølund, JF Højen… - Basic & clinical …, 2021 - Wiley Online Library
… When used in the treatment of acute worsening of chronic pancreatitis or postoperative
reflux oesophagitis, the recommended dosage is 300-600 mg/day in three dosages of 100-200 …

Two-dose SARS-CoV-2 vaccine effectiveness with mixed schedules and extended dosing intervals: test-negative design studies from British Columbia and Quebec …

DM Skowronski, S Setayeshgar, Y Febriani, M Ouakki… - MedRxiv, 2021 - medrxiv.org
… of mRNA and/or ChAdOx1 vaccines gave excellent protection against … doses improved VE
and may be optimal in most circumstances. Findings indicate prolonged two-dose protection

[HTML][HTML] Humoral and cellular immune response and safety of two-dose SARS-CoV-2 mRNA-1273 vaccine in solid organ transplant recipients

VG Hall, VH Ferreira, M Ierullo, T Ku, T Marinelli… - American Journal of …, 2021 - Elsevier
… of immune protection from symptomatic SARS-CoV-2 infection … ) received both doses of the
vaccine at the recommended 1-… the first dose and so did not receive a second dose. Baseline …

Fifth-week immunogenicity and safety of anti-SARS-CoV-2 BNT162b2 vaccine in patients with multiple myeloma and myeloproliferative malignancies on active …

F Pimpinelli, F Marchesi, G Piaggio… - Journal of hematology & …, 2021 - Springer
… inhibitors (TKIs) versus SARS-CoV-2 infection in patients … expected problems in terms of
safety, the efficacy data have to be … A real uncertainty exists about the optimal timing, dosing and …

Molnupiravir—a novel oral anti-SARS-CoV-2 agent

CC Lee, CC Hsieh, WC Ko - Antibiotics, 2021 - mdpi.com
… Focusing on adults with early symptomatic COVID-19, the optimal dose and safety of
molnupiravir were evaluated through a multicenter, multistage, open-label, phase-Ib/IIa randomized …

Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects

H Qian, Y Wang, M Zhang, Y Xie, Q Wu… - Acta Pharmacologica …, 2022 - nature.com
… To obtain the best experience, we recommend you use a … the safety results of the 25 mg
dose group, as well as the ongoing clinical trial in Uzbekistan, adjustment was made for the dose