Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell
receptor … ACE2-binding mode of the SARS-CoV-2 RBD is nearly identical to that of the SARS-…

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

DJ Benton, AG Wrobel, P Xu, C Roustan, SR Martin… - Nature, 2020 - nature.com
… binding on the overall spike conformation. To examine this interaction between the SARS-CoV-2
spike protein and its receptor, we mixed the ectodomains of furin-cleaved spike with the …

Differences and similarities between SARS-CoV and SARS-CoV-2: spike receptor-binding domain recognition and host cell infection with support of cellular serine …

GA Rossi, O Sacco, E Mancino, L Cristiani, F Midulla - Infection, 2020 - Springer
… , SARSCoV-2 infection appears to be much more contagious. Moreover, many SARS-CoV-2 …
a more effective SARS-CoV-2 immune surveillance evasion than SARS-CoV. This paper …

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARSCoV‐2

Z Liu, X Xiao, X Wei, J Li, J Yang, H Tan… - Journal of medical …, 2020 - Wiley Online Library
… This study focuses on comparisons of the spike sequences between SARS-CoV-2 with
SARS-CoV, bat SARS-like CoV, and other coronaviruses, which are helpful for evolutionary …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… with SARS-CoV-1 or SARS-CoV-2 spike proteins to assess … SARS-CoV-2 spike protein
had antibodies that bound well to the RBD of SARS-CoV-2 and poorly to the RBDs of SARS-CoV-…

Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - BioRxiv, 2020 - biorxiv.org
… Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific
human monoclonal antibody. Emerg Microbes Infect 9, 382–385, doi:10.1080/22221751.2020.…

[HTML][HTML] Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

JT Ortega, ML Serrano, FH Pujol, HR Rangel - EXCLI journal, 2020 - ncbi.nlm.nih.gov
… the Bat-CoV to this receptor. The data presented in this study suggest a higher affinity of …
SARS-Cov-2 spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike

Human coronavirus spike protein-host receptor recognition

L Guruprasad - Progress in biophysics and molecular biology, 2021 - Elsevier
… disease 2019 (COVID-19) caused by novel SARS coronavirus-2 (SARS-CoV-2). COVID-19
was first reported from Wuhan City, Hubei-1 Province, China, during December 2019 and in …

Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

L Piccoli, YJ Park, MA Tortorici, N Czudnochowski… - Cell, 2020 - cell.com
… In a cohort of 647 SARS-CoV-2-infected subjects, we found that both the magnitude …
SARS-CoV-2 spike (S) and nucleoprotein and nAb titers correlate with clinical scores. The receptor-…

SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in their requirements for receptor expression and proteolytic activation

BF Hörnich, AK Großkopf, S Schlagowski… - Journal of …, 2021 - Am Soc Microbiol
… ), the receptor binding … spike proteins of SARS-CoV-2 and SARS-CoV and the SARS2-S
cleavage site mutants analyzed in this study (not exactly drawn to scale). (B) Expression of spike