[HTML][HTML] New approach methodologies in human regulatory toxicology–Not if, but how and when!

S Schmeisser, A Miccoli, M von Bergen… - Environment …, 2023 - Elsevier
… regarding the use of NAMs in the regulatory context were presented. The symposium …
systematically analyzed the technological readiness level as well as conceptual and regulatory

Systematic reconstruction of cellular trajectories across mouse embryogenesis

C Qiu, J Cao, BK Martin, T Li, IC Welsh, S Srivatsan… - Nature …, 2022 - nature.com
… Motivated by this, we sought to systematically identify TFs that are candidates for specifying
each newly emerging cell type 51,52 . For each branchpoint at which a new cell type first …

[HTML][HTML] Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions

KM Girskis, AB Stergachis, EM DeGennaro, RN Doan… - Neuron, 2021 - cell.com
… to function as regulatory elements that drive human-specific gene regulatory programs.
We … Furthermore, we demonstrate PPP1R17 to be a putative HAR-regulated gene that has …

CRISPR screen in regulatory T cells reveals modulators of Foxp3

JT Cortez, E Montauti, E Shifrut, J Gatchalian, Y Zhang… - Nature, 2020 - nature.com
… Understanding the fundamental regulators of Foxp3 is critical… To identify potential regulators
of Foxp3 stability, we … MAGeCK software 7 systematically identified sgRNAs that were …

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

MA La Merrill, LN Vandenberg, MT Smith… - Nature Reviews …, 2020 - nature.com
… , the recommended KCs of EDCs approach can systematically identify gaps in data and
therefore set research priorities through the process of hazard identification. The utility of this …

Endocrine-disrupting chemicals: economic, regulatory, and policy implications

CD Kassotis, LN Vandenberg, BA Demeneix… - The lancet Diabetes & …, 2020 - thelancet.com
… We review the approaches used for the regulation of EDCs in the EU and the USA, which
have the most well developed and far-reaching regulations. We also identify regulatory

Systematic over‐crediting in California's forest carbon offsets program

G Badgley, J Freeman, JJ Hamman… - Global Change …, 2022 - Wiley Online Library
… We also identify a handful of projects as under-credited. Several of these projects, such as
… Across the program as a whole, we find evidence of systematic over-crediting (Figure 5). Of …

[HTML][HTML] A systematic review of salt reduction initiatives around the world: a midterm evaluation of progress towards the 2025 global non-communicable diseases salt …

JA Santos, D Tekle, E Rosewarne, N Flexner… - Advances in …, 2021 - Elsevier
… This review aims to identify all national salt reduction initiatives around the world in 2019,
and to quantify countries' progress in achieving the salt reduction target. Relevant data were …

Structural cells are key regulators of organ-specific immune responses

T Krausgruber, N Fortelny, V Fife-Gernedl… - Nature, 2020 - nature.com
… To advance our understanding of immunology outside the haematopoietic system, here
we systematically investigate the regulation of immune genes in the three major types of …

Roles of transposable elements in the regulation of mammalian transcription

R Fueyo, J Judd, C Feschotte, J Wysocka - Nature reviews Molecular …, 2022 - nature.com
systematic interrogation of the regulatory activities of TEs. In this Review, we discuss diverse
mechanisms by which TEs contribute to transcription regulation. … to novel regulatory genes, …