Development of therapeutic antibodies for the treatment of diseases

RM Lu, YC Hwang, IJ Liu, CC Lee, HZ Tsai… - Journal of biomedical …, 2020 - Springer
… This review summarizes the latest market trends and outlines the preeminent antibody
engineering technologies used in the development of therapeutic antibody drugs, such as …

Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease

T Athar, K Al Balushi, SA Khan - Molecular biology reports, 2021 - Springer
… The currently approved drugs act on one target (one drug one … therapeutic strategies to
design and develop drugs capable of hitting at more than one target [8, 10]. Multi-target drugs (…

Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases

RM Meganck, RS Baric - Nature medicine, 2021 - nature.com
… to integrate efforts across disciplines to develop drugs and vaccines. Similar efforts are … with
regulatory agencies to facilitate rapid therapeutic development. Commercial partners provide …

An update on current therapeutic drugs treating COVID-19

R Wu, L Wang, HCD Kuo, A Shannar, R Peter… - Current pharmacology …, 2020 - Springer
… These drugs and therapeutic agents include antiviral agents (… updated therapeutic drugs to
prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs

Anti-tuberculosis treatment strategies and drug development: challenges and priorities

VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
… In this Review, we highlight the benefits and challenges of ‘one-size-fits-all’ regimens and
treatment duration versus individualized therapy based on disease severity and host and …

[HTML][HTML] Why 90% of clinical drug development fails and how to improve it?

D Sun, W Gao, H Hu, S Zhou - Acta Pharmaceutica Sinica B, 2022 - Elsevier
drug development process leading to high failure? How can we improve the success rate of
clinical drug development… However, drug optimization in other therapeutic areas rarely adapt …

A decade of FDA-approved drugs (2010–2019): trends and future directions

DG Brown, HJ Wobst - Journal of medicinal chemistry, 2021 - ACS Publications
… An analysis of therapy areas was done for the 289 NMEs and the 89 BLAs approved from
2010 to 2019. The top five therapy areas for new drug approvals by the FDA (NME and BLA) …

Recent developments on therapeutic and diagnostic approaches for COVID-19

J Majumder, T Minko - The AAPS journal, 2021 - Springer
… known antiviral drugs, their combination, as well as development of … therapy of COVID-19.
We have summarized recent progress on the conventional therapeutics such as antiviral drugs

Metalloproteinases and their inhibitors: potential for the development of new therapeutics

M Raeeszadeh-Sarmazdeh, LD Do, BG Hritz - Cells, 2020 - mdpi.com
therapeutic applications for metalloproteases as targets for inhibition and as tools for drug
… This finding clarified the role of NF-kB inhibition through drug treatment, and it was also …

Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease

CK Huang, S Kafert-Kasting, T Thum - Circulation research, 2020 - Am Heart Assoc
… In summary, a combination of novel therapeutic RNA targets, large-animal models, ex vivo …
in the development of noncoding RNA-based next-generation therapeutics for cardiovascular …