Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
cytokine release in response to viral infection, a condition known as cytokine release
syndrome (CRS) or cytokine storm… timed anti-inflammatory therapeutic strategies could improve …

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
… ill COVID-19 patients, cytokine storm and cytokine dysregulation lead to remarkable
pathological consequences. Indeed, the cytokine storm elicits immunological changes that can …

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine stormstherapeutic

[HTML][HTML] Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… If the inflammatory reaction is very pronounced, an ultimately uncontrolled release of
proinflammatory cytokines leads to cytokine storm with the known potentially lethal courses [168]. …

[HTML][HTML] Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position …

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… overview of the cytokine storm and its implications in COVID-… that could be targeted for
therapy. Leveraging expert opinion, … on cytokine storm from both a prognostic and therapeutic

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… One of the main features of ARDS is the cytokine storm - an uncontrolled systemic … -inflammatory
cytokines and chemokines by immune effector cells [5]. High blood levels of cytokines

Cytokine storm in COVID-19: Potential therapeutics for immunomodulation

MM Rana - Journal of Research in Clinical Medicine, 2020 - library.2pressrelease.co.in
… Another way to restrain the excessive level of cytokine signalling or cytokine storm is the
use of Janus kinase inhibitors (JAKi).Most JAK inhibitors are specifically effective at JAK1 and …

Constitutive inflammatory cytokine storm: a major threat to human health

KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
… of proinflammatory cytokines such as IL-3 and IL-6 causes organ … the regulators of cytokine
release, its types, its implications on … cytokine storm and its implications on human health. …

Therapeutic implications of ongoing alveolar viral replication in COVID-19

D McGonagle, MF Kearney, A O'Regan… - The Lancet …, 2022 - thelancet.com
… approximately 10 000 pg/mL typically observed in cytokine storm syndromes in patients
receiving CAR T-cell therapy. Low IL-6 concentrations have been used to stratify patients with …

[HTML][HTML] Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

M Soy, G Keser, P Atagündüz, F Tabak… - Clinical …, 2020 - Springer
… There is no consensus or suggestion on which terminology should be used: cytokine storm,
MAS, or sHLH? We chose to use the term cytokine storm secondary to COVID-19; however, …