Therapeutic targets in lung tissue remodelling and fibrosis

G Liu, AM Philp, T Corte, MA Travis, H Schilter… - Pharmacology & …, 2021 - Elsevier
… involving tissue remodelling and fibrosis are major features of many pulmonary diseases, …
of tissue remodelling that results in symptoms and impaired lung function in these diseases. …

Vascular remodelling in idiopathic pulmonary fibrosis patients and its detrimental effect on lung physiology: potential role of endothelial-to-mesenchymal transition

AV Gaikwad, W Lu, S Dey, P Bhattarai… - ERJ Open …, 2022 - Eur Respiratory Soc
pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic … -based quantitation of pulmonary
arterial remodelling in IPF … for pulmonary arteries was conducted in NC and IPF tissues. …

… of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis

DJ Leeming, F Genovese, JMB Sand… - Respiratory …, 2021 - Springer
… (ECM) remodelling of the lungs related to lung function decline in pulmonary fibrosis (PF)…
A range of non-invasive serological biomarkers, reflecting tissue remodelling, and fibrosis

The extracellular matrix and mechanotransduction in pulmonary fibrosis

Z Deng, MW Fear, YS Choi, FM Wood… - The international journal …, 2020 - Elsevier
… only a characteristic feature of end stage fibrotic remodelling, but that ECM components also
drive … matrix stiffness in the lung tissues of pulmonary fibrosis affect cell phenotype is force-…

Multi-step extracellular matrix remodelling and stiffening in the development of idiopathic pulmonary fibrosis

C Júnior, A Ulldemolins, M Narciso… - International Journal of …, 2023 - mdpi.com
Fibrosis is a product of the permanent tissue remodelling associated with unresolved
inflammation [31]. In fact, several studies have shown that inflammation and the presence of …

Endothelial-to-mesenchymal transition: a precursor to pulmonary arterial remodelling in patients with idiopathic pulmonary fibrosis

AV Gaikwad, W Lu, S Dey, P Bhattarai… - ERJ open …, 2023 - Eur Respiratory Soc
Background We have previously reported arterial remodelling in patients with idiopathic
pulmonary fibrosis (IPF) and suggested that endothelial-to-mesenchymal transition (EndMT) …

[HTML][HTML] Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension

AYY Tam, AL Horwell, SL Trinder, K Khan, S Xu… - The international journal …, 2021 - Elsevier
pulmonary hypertension, CCN2 gene deletion resulted in a significant decrease in pulmonary
vessel remodelling… CCN2 in pulmonary fibrosis and in vessel remodelling associated with …

Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis

RJ Hewitt, F Puttur, DCA Gaboriau, F Fercoq… - Nature …, 2023 - nature.com
… cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). …
Here, we reveal a potential mechanism by which KRT5 + cells migrate within the fibrotic lung…

Pulmonary fibroelastotic remodelling revisited

P Braubach, C Werlein, SE Verleden, I Maerzke… - Cells, 2021 - mdpi.com
… Of these, 6 were iPPFE and 25 had PPFE-like pulmonary fibrosis due to other causes: with
… in lung parenchyma with loss of original tissue replaced by collagenous and elastic fibers. …

When things go wrong: exploring possible mechanisms driving the progressive fibrosis phenotype in interstitial lung diseases

M Selman, A Pardo - European Respiratory Journal, 2021 - Eur Respiratory Soc
remodelling tissue in pulmonary fibrosis. The study revealed a previously undescribed
population of KRT5 − /KRT17 + epithelial cells that expressed collagen type I α1 chain (COL1A1), …