… We reveal key cell type-specific transcription factors and major gene-regulatory circuits for
… critical stages and drivers of early kidney development 4 , that have been essential for the …

… -seq can predict the transcription factors that drive cell-type-specificity, which may improve
our understanding of kidney development and directed differentiation of kidney organoids. We …

… kidney disease, yet the mechanism of kidney dysfunction is poorly understood. In the present
study, we define the genetic association with kidney … in 443 kidneys, transcriptome in 686 …

… mammalian kidney development and adult kidney in health … kidney diseases, through the
mechanisms of chromatin modification, transcriptional regulation, post-transcriptional control, …

… and transcriptional profiles of the cells in the CTAL-DCT-CNT region, we developed the …
nephron progenitors and ureteric bud during kidney development. Among DCT1 cells, we also …

… the transcriptional consequences of BET inhibition in kidney … transcriptional profiling of
vehicle- and JQ1-treated kidney … these transcription factors at enhancer sites in the kidney and …

… Moreover, AKI caused the formation of “mixed-identity cells” (expressing markers of different
renal cell types) that are normally seen only during early kidney development. The injured …

… of acute kidney injury (AKI) and chronic kidney disease, as well as in abnormal kidney repair
after AKI. Multiple quality control mechanisms, including antioxidant defence, protein quality …

… This analysis delineated two distinct transcriptional trajectories in response to human AKI
(7): successful repair [1] or disease progression via a transition state [2] to chronic injury [3]. …

… In this study, we revealed a brain-specific transcription factor Pou4f1 as the key regulator
by which TGF-β1/Smad3 signaling executes MMT. Macrophage-specific silencing of Pou4f1 …