[HTML][HTML] SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
viral SARS-CoV-2 pathogenesis in COVID-19. Accessory proteins in SARS-CoV-2 consist of
eleven viral proteins … current knowledge of SARS-CoV-2 accessory proteins is summarized …

SARS-CoV-2 mutations and their viral variants

B Cosar, ZY Karagulleoglu, S Unal, AT Ince… - Cytokine & growth factor …, 2022 - Elsevier
… Genomic and subgenomic RNA synthesis takes place in the synthesis of viral proteins. Then,
with the help of ribosomes, viral RNAs are transmitted and viral proteins are synthesized. 8. …

Structure and function of major SARS-CoV-2 and SARS-CoV proteins

R Gorkhali, P Koirala, S Rijal… - … and biology insights, 2021 - journals.sagepub.com
… The sequencing revealed that the novel virus had most proteins homologous to SARS-CoV, …
(I) Finally, replicated RNA and other translated viral proteins assembled into a new virus. …

[HTML][HTML] SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
… Here, we show that SARS-CoV-2 can block IRF3 and NF-κB activation early during virus
infection. We also identify that the SARS-CoV-2 viral proteins NSP1 and NSP13 can block …

[HTML][HTML] A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins

J Zhang, R Cruz-Cosme, MW Zhuang, D Liu… - Signal transduction and …, 2020 - nature.com
… We identified ORF3a to be the viral protein that is associated with the formation of … SARS-CoV-2
and applied a systemic IFA to characterize the subcellular distribution of the viral proteins

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

A Tidu, A Janvier, L Schaeffer, P Sosnowski, L Kuhn… - Rna, 2021 - rnajournal.cshlp.org
… Here, we confirm that viral translation is maintained in the presence of NSP1 and we show …
5′UTR of SARS-CoV-2. Only the apical part of SL1 is required for viral translation. We further …

[HTML][HTML] Structural biology of SARS-CoV-2 and implications for therapeutic development

H Yang, Z Rao - Nature Reviews Microbiology, 2021 - nature.com
… In this Review, we delineate the structural features of SARS-CoV-2 from the whole viral
particle to the individual viral proteins and discuss their functions as well as their potential as …

[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19

R Yadav, JK Chaudhary, N Jain, PK Chaudhary… - Cells, 2021 - mdpi.com
… associated with membrane such as S, M, and E are synthesized by endoplasmic
reticulum-bound ribosomes, whereas other viral proteins, including N protein, are translated by free …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
… of viral proteins and relevant host factors. The trimeric spike (S) … viral entry process.
Here we summarize our current knowledge on the structure of the SARS-CoV-2 S protein

Effects of SARSCoV‐2 mutations on protein structures and intraviral proteinprotein interactions

S Wu, C Tian, P Liu, D Guo, W Zheng… - Journal of medical …, 2021 - Wiley Online Library
… Overall, our findings suggest that SARS-CoV-2 mutations could change viral protein
structure, binding affinity, and hot spots of the interface, thereby might have impacts on …