[HTML][HTML] Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA

S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong… - Molecular cell, 2020 - cell.com
… We show here that among all viral proteins, Nsp1 has the largest impact on host viability in
the cells of human lung origin. Differential expression analysis of mRNA-seq data revealed …

The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles

B Boson, V Legros, B Zhou, E Siret, C Mathieu… - Journal of Biological …, 2021 - ASBMB
… We therefore investigated the cellular localization of SARS-CoV-2 S … viral proteins, as
compared with full-length virus. First, we found that the intracellular S detected in SARS-CoV-2-…

Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
SARS-CoV-2 protein (and in more than 50% of conducted screens) are shown. For viral
proteins … of the cellular protein divided by the number of unique viral proteins with which it was …

Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 human ACE2 transgenic mice

JA Silvas, DM Vasquez, JG Park, K Chiem… - Journal of …, 2021 - Am Soc Microbiol
… , severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) … of SARS-CoV-2 and the
contribution of viral proteins to … SARS-CoV-2 accessory open reading frame (ORF) proteins

Evasion of type I interferon by SARS-CoV-2

H Xia, Z Cao, X Xie, X Zhang, JYC Chen, H Wang… - Cell reports, 2020 - cell.com
… We identify two sets of viral proteins that antagonize IFN-I signaling through blocking
signal transducer and activator of transcription 1 (STAT1)/STAT2 phosphorylation or nuclear …

[HTML][HTML] The coding capacity of SARS-CoV-2

Y Finkel, O Mizrahi, A Nachshon… - Nature, 2021 - nature.com
… from SARS-CoV-2 independently of the host cell and the viral … the translation landscape of
SARS-CoV-2. Comprehensive … investigation of viral proteins and for deciphering virus–host …

Coronaviruses and sars-cov-2

M Hasöksüz, S Kilic, F Saraç - Turkish journal of medical …, 2020 - journals.tubitak.gov.tr
… of a coronavirus S protein vary depending on the virus; some … viruses, SARSCoV-2 and bat
coronavirus RaTG13, are closely related [50]. It was also reported that the SARS-CoV-2 virus

Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity

MR Islam, MN Hoque, MS Rahman, ASMRU Alam… - Scientific reports, 2020 - nature.com
… Nevertheless, several reports predict possible adaptation at the nt, amino acid (aa), and
structural heterogeneity in the viral proteins, especially in the S protein 8,9 . Interestingly, Shen …

Distinct conformational states of SARS-CoV-2 spike protein

Y Cai, J Zhang, T Xiao, H Peng, SM Sterling… - Science, 2020 - science.org
coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion
between viral … of the structure-function relationships of viral proteins and relevant host factors. …

[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Y Huang, C Yang, X Xu, W Xu, S Liu - Acta Pharmacologica Sinica, 2020 - nature.com
… conserved regions of viral proteins. Peptides derived from the HR2 region of class I … viral S
protein is trypsin [49]. In summary, the S protein of SARS-CoV-2 is similar to that of SARS-CoV