The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
… with SARS-CoV-1 or SARS-CoV-2 spike proteins to assess … SARS-CoV-2 spike protein
had antibodies that bound well to the RBD of SARS-CoV-2 and poorly to the RBDs of SARS-CoV-…

Structure of SARS-CoV-2 membrane protein essential for virus assembly

Z Zhang, N Nomura, Y Muramoto, T Ekimoto… - Nature …, 2022 - nature.com
… of M protein-driven virus assembly are largely unknown. Here, we report the cryo-electron
microscopy structure of the SARS-CoV-2 M protein in two different conformations. M protein

[PDF][PDF] Properties of coronavirus and SARS-CoV-2

YA Malik - The Malaysian journal of pathology, 2020 - mjpath.org.my
… The genome sequences suggest presence of a virus closely related to SARS- CoV. On 11
… Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two …

[HTML][HTML] Coronavirus SARS-CoV-2 and Covid-19

A Uzunian - Jornal Brasileiro de Patologia e Medicina Laboratorial, 2020 - SciELO Brasil
… of another viral protein, the ORF7 - required for viral release -; it … viruses from being captured
and allowing more viruses to escape. Researchers also discovered that the ORF7 protein

Virology, transmission, and pathogenesis of SARS-CoV-2

M Cevik, K Kuppalli, J Kindrachuk, M Peiris - bmj, 2020 - bmj.com
… Covid-19 leads to an antibody response to a range of viral proteins, but the spike (S) protein
and nucleocapsid are those most often used in serological diagnosis. Few antibodies are …

[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus

H Yao, Y Song, Y Chen, N Wu, J Xu, C Sun, J Zhang… - Cell, 2020 - cell.com
… elucidation of SARS-CoV-2 proteins, the detailed architecture of the intact virus remains to
be unveiled. Here we report the molecular assembly of the authentic SARS-CoV-2 virus using …

Phosphoregulation of phase separation by the SARS-CoV-2 N protein suggests a biophysical basis for its dual functions

CR Carlson, JB Asfaha, CM Ghent, CJ Howard… - Molecular cell, 2020 - cell.com
… the N protein of SARS-CoV-2, together with viral RNA, forms biomolecular condensates.
Unmodified N protein forms … The N protein is the most abundant viral protein in the infected cell ( …

Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

J Li, M Guo, X Tian, X Wang, X Yang, P Wu, C Liu… - Med, 2021 - cell.com
… The COVID-19 pandemic is caused by SARS-CoV-2, but little is known about the
functions of its viral proteins. The authors characterized the SARS-CoV-2 intraviral and virus-host …

[HTML][HTML] Machine learning techniques for sequence-based prediction of viral–host interactions between SARS-CoV-2 and human proteins

L Dey, S Chakraborty, A Mukhopadhyay - Biomedical journal, 2020 - Elsevier
… A comprehension of how SARS-CoV-2 virus proteins interact … Protein-Protein Interaction
(PPI) is one way the viruses … human proteins of the SARS-CoV-2 virus based on their protein

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV

KG Lokugamage, A Hage, M de Vries… - Journal of …, 2020 - Am Soc Microbiol
… Finally, we examined homology between SARS-CoV and SARS-CoV-2 in viral proteins
shown to be interferon antagonists. The absence of an equivalent open reading frame 3b (…