[HTML][HTML] SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

J Mu, Y Fang, Q Yang, T Shu, A Wang, M Huang, L Jin… - Cell discovery, 2020 - nature.com
… -2 at MOI of 0.1, and the viral RNA accumulation in cells were … that viral RNA replication was
significantly elevated in SARS-CoV-2-… Coronavirus N protein is a multifunctional viral protein

[HTML][HTML] Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
SARS-CoV-2 or some critical proteins for viral pathogenesis, providing insights into the
mechanisms underlying viral … treatment of the disease caused by the viral variants are imperative. …

Syncytia formation by SARSCoV‐2‐infected cells

J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
… The viral and … SARS-CoV-2-infected cells express the Spike protein (S) at their surface
and fuse with ACE2-positive neighboring cells. Expression of S without any other viral proteins

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

J Mu, J Xu, L Zhang, T Shu, D Wu, M Huang… - Science China Life …, 2020 - Springer
… -2 N contains VSR activity, we sought to examine the mechanism of how SARSCoV-2 N
antagonizes RNAi. During the dsRNA/shRNAinduced RNAi, dsRNA/shRNA is initially …

Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy

D Benvenuto, S Angeletti, M Giovanetti, M Bianchi… - Journal of Infection, 2020 - Elsevier
SARS-CoV-2 mutations of non-structural viral proteins, NSP6 and an aminoacidic region near
ORF 10, with particular interest into the former protein… stable binding of the protein to ER. It …

A SARS-CoV-2–host proximity interactome

P Samavarchi-Tehrani, H Abdouni, JDR Knight… - BioRxiv, 2020 - biorxiv.org
viral proteins in the context of host proteome remodelling. In summary, our dataset identifies
numerous high confidence proximity partners for SARS-CoV-2 viral proteins, … virus proteins

[HTML][HTML] Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

S Kang, M Yang, Z Hong, L Zhang, Z Huang… - … Pharmaceutica Sinica B, 2020 - Elsevier
… Currently, there is no specific viral protein-targeted therapeutics. Viral nucleocapsid protein
is … will aid in the development of new drugs that interfere with viral N protein in SARS-CoV-2. …

SARS-CoV-2 nonstructural protein 1 inhibits the interferon response by causing depletion of key host signaling factors

A Kumar, R Ishida, T Strilets, J Cole… - Journal of …, 2021 - Am Soc Microbiol
… plasmids for all known proteins of SARS-CoV-2 with C-… viral proteins that inhibit IFN
signaling, we performed ISRE reporter assays in cells expressing individual SARS-CoV-2 proteins

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Y Zhang, Y Chen, Y Li, F Huang… - Proceedings of the …, 2021 - National Acad Sciences
… As the function of almost all structural and nonstructural viral proteins of SARS-CoV has
been identified, we reasoned that the possible HIV-1 Nef- or Vpu-like function, if it exists, would …

[HTML][HTML] Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

B Meyer, J Chiaravalli, S Gellenoncourt… - Nature …, 2021 - nature.com
… We identify previously unknown cleavage sites in multiple viral proteins, including major
antigens S and N: the main targets for vaccine and antibody testing efforts. We discover …