Physiologically based pharmacokinetic modeling of transporter-mediated hepatic clearance and liver partitioning of OATP and OCT substrates in cynomolgus …
BL Morse, JG MacGuire, AM Marino, Y Zhao, M Fox… - The AAPS Journal, 2017 - Springer
In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …
Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus …
BL Morse, JG MacGuire, AM Marino… - The AAPS …, 2017 - pubmed.ncbi.nlm.nih.gov
In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …
Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus …
BL Morse, JG MacGuire, AM Marino, Y Zhao… - The AAPS …, 2017 - europepmc.org
In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …
prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed …