[HTML][HTML] Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E Ten Hacken, R Valentin, FFD Regis, J Sun, S Yin… - JCI insight, 2018 - ncbi.nlm.nih.gov
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E Ten Hacken, R Valentin, FFD Regis… - JCI …, 2018 - mdanderson.elsevierpure.com
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.

E Ten Hacken, R Valentin, FFD Regis, J Sun, S Yin… - JCI Insight, 2018 - europepmc.org
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E Hacken, R Valentin, FFD Regis, J Sun, S Yin… - JCI Insight, 2018 - escholarship.org
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E Ten Hacken, R Valentin, FFD Regis, J Sun… - JCI …, 2018 - einstein.elsevierpure.com
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

[HTML][HTML] Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E ten Hacken, R Valentin, FFD Regis, J Sun, S Yin… - JCI …, 2018 - Am Soc Clin Investig
The therapeutic landscape of the mature B cell malignancy chronic lymphocytic leukemia
(CLL) has changed greatly over the last decade due to the introduction of novel inhibitors …

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E Ten Hacken, R Valentin, FFD Regis, J Sun… - JCI …, 2018 - pubmed.ncbi.nlm.nih.gov
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

[HTML][HTML] Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

E ten Hacken, R Valentin, FFD Regis, J Sun, S Yin… - JCI …, 2018 - Am Soc Clin Investig
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …

Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies.

E Ten Hacken, R Valentin, FFD Regis, J Sun, S Yin… - JCI Insight, 2018 - europepmc.org
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key
challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic …