Physiologically based pharmacokinetic modeling as a tool to predict drug interactions for antibody-drug conjugates

Y Chen, D Samineni, S Mukadam, H Wong… - Clinical …, 2015 - Springer
Abstract Background and Objectives Monomethyl auristatin E (MMAE, a cytotoxic agent),
upon releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is …
被引用次数：42 相关文章

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Y Chen, D Samineni, S Mukadam, H Wong… - Clinical …, 2015 - hero.epa.gov
Abstract Background and Objectives Monomethyl auristatin E (MMAE, a cytotoxic agent),
upon releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is …

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Y Chen, D Samineni, S Mukadam, H Wong… - Clinical …, 2015 - infona.pl
Background and Objectives Monomethyl auristatin E (MMAE, a cytotoxic agent), upon
releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is …

Physiologically based pharmacokinetic modeling as a tool to predict drug interactions for antibody-drug conjugates.

Y Chen, D Samineni, S Mukadam, H Wong… - Clinical …, 2015 - europepmc.org
Methods A PBPK model linking antibody-conjugated MMAE (acMMAE) to its catabolite
unconjugated MMAE associated with vc-MMAE ADCs was developed using a mixed'bottom …

[引用][C] Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Y Chen, D Samineni, S Mukadam, H Wong… - Clinical …, 2014 - cir.nii.ac.jp
Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for
Antibody-Drug Conjugates | CiNii Research CiNii 国立情報学研究所 学術情報ナビゲータ[サイニィ …

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Y Chen, D Samineni, S Mukadam… - Clinical …, 2015 - search.proquest.com
Abstract Background and Objectives Monomethyl auristatin E (MMAE, a cytotoxic agent),
upon releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is …

Physiologically based pharmacokinetic modeling as a tool to predict drug interactions for antibody-drug conjugates

Y Chen, D Samineni, S Mukadam… - Clinical …, 2015 - pubmed.ncbi.nlm.nih.gov
Background and objectives Monomethyl auristatin E (MMAE, a cytotoxic agent), upon
releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is …

Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates.

Y Chen, D Samineni, S Mukadam… - Clinical …, 2015 - search.ebscohost.com
Abstract Background and Objectives: Monomethyl auristatin E (MMAE, a cytotoxic agent),
upon releasing from valine-citrulline-MMAE (vc-MMAE) antibody-drug conjugates (ADCs), is …

[引用][C] Physiologically Based Pharmacokinetic Modeling as a Tool to Predict Drug Interactions for Antibody-Drug Conjugates

Y Chen, D Samineni, S Mukadam, H Wong… - Clinical …, 2015 - Adis International