The dCMP deaminase DCTD and the E3 ligase TOPORS are central mediators of decitabine cytotoxicity

CJ Carnie, MJ Götz, CS Palma-Chaundler, P Weickert… - bioRxiv, 2023 - biorxiv.org
Abstract The nucleoside decitabine (5-aza-dC) is used to treat several hematological
cancers. Upon triphosphorylation and incorporation into DNA, 5-aza-dC induces covalent …
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The dCMP deaminase DCTD and the E3 ligase TOPORS are central mediators of decitabine cytotoxicity

CJ Carnie, MJ Gotz, CS Palma-Chaundler, P Weickert… - 2023 - europepmc.org
The nucleoside decitabine (5-aza-dC) is used to treat several hematological cancers. Upon
triphosphorylation and incorporation into DNA, 5-aza-dC induces covalent DNMT1 DNA …