Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
Proteins are marginally stable, and an understanding of the sequence determinants for
improved protein solubility is highly desired. For enzymes, it is well known that many …
improved protein solubility is highly desired. For enzymes, it is well known that many …
[PDF][PDF] Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmitha, JP Bacikb, EE Wrenbeckc… - PNAS, 2017 - academia.edu
Results Deep Mutational Scanning for Solubility. We performed deep mutational scanning
on two full-length enzymes: a 263-residue TEM-1 beta-lactamase (BLA) variant and a 439 …
on two full-length enzymes: a 263-residue TEM-1 beta-lactamase (BLA) variant and a 439 …
[HTML][HTML] Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - ncbi.nlm.nih.gov
Results Deep Mutational Scanning for Solubility. We performed deep mutational scanning
on two full-length enzymes: a 263-residue TEM-1 beta-lactamase (BLA) variant and a 439 …
on two full-length enzymes: a 263-residue TEM-1 beta-lactamase (BLA) variant and a 439 …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning.
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - europepmc.org
Proteins are marginally stable, and an understanding of the sequence determinants for
improved protein solubility is highly desired. For enzymes, it is well known that many …
improved protein solubility is highly desired. For enzymes, it is well known that many …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - cir.nii.ac.jp
抄録< jats: title> Significance</jats: title>< jats: p> Enzymes find utility as therapeutics and for
the production of specialty chemicals. Changing the amino acid sequence of an enzyme can …
the production of specialty chemicals. Changing the amino acid sequence of an enzyme can …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - ui.adsabs.harvard.edu
Enzymes find utility as therapeutics and for the production of specialty chemicals. Changing
the amino acid sequence of an enzyme can increase solubility, but many such mutations …
the amino acid sequence of an enzyme can increase solubility, but many such mutations …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - pubmed.ncbi.nlm.nih.gov
Proteins are marginally stable, and an understanding of the sequence determinants for
improved protein solubility is highly desired. For enzymes, it is well known that many …
improved protein solubility is highly desired. For enzymes, it is well known that many …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - experts.umn.edu
Proteins are marginally stable, and an understanding of the sequence determinants for
improved protein solubility is highly desired. For enzymes, it is well known that many …
improved protein solubility is highly desired. For enzymes, it is well known that many …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - osti.gov
Significance Enzymes find utility as therapeutics and for the production of specialty
chemicals. Changing the amino acid sequence of an enzyme can increase solubility, but …
chemicals. Changing the amino acid sequence of an enzyme can increase solubility, but …
Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
JR Klesmith, JP Bacik, EE Wrenbeck… - Proceedings of the …, 2017 - JSTOR
Proteins are marginally stable, and an understanding of the sequence determinants for
improved protein solubility is highly desired. For enzymes, it is well known that many …
improved protein solubility is highly desired. For enzymes, it is well known that many …