Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff
GE Boyle, K Sitko, JG Galloway, HK Haddox… - bioRxiv, 2023 - biorxiv.org
Cytochrome P450s (CYPs) are a family of enzymes responsible for metabolizing nearly 80%
of small molecule drugs. Variants in CYPs can substantially alter drug metabolism, which …
of small molecule drugs. Variants in CYPs can substantially alter drug metabolism, which …
Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff
GE Boyle, K Sitko, JG Galloway, HK Haddox… - 2023 - europepmc.org
Cytochrome P450s (CYPs) are a family of enzymes responsible for metabolizing nearly 80%
of small molecule drugs. Variants in CYPs can substantially alter drug metabolism, which …
of small molecule drugs. Variants in CYPs can substantially alter drug metabolism, which …