Identification of cytochrome P450-mediated drug–drug interactions at risk in cases of gene polymorphisms by using a quantitative prediction model

N Fermier, L Bourguignon, S Goutelle, N Bleyzac… - Clinical …, 2018 - Springer
Abstract Background and Objective The magnitude of drug–drug interactions mediated by
cytochrome P450 (CYP) may depend on the genotype of polymorphic cytochromes. The …
被引用次数：10 相关文章

Identification of Cytochrome P450-Mediated Drug-Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model.

N Fermier, L Bourguignon, S Goutelle… - Clinical …, 2018 - europepmc.org
Methods The in-vivo mechanistic static model was used to predict the area under the curve
ratio of drug-drug interactions. Five cytochromes (CYP3A4/5, 2D6, 2C9, 2C19, 1A2) and five …

Identification of Cytochrome P450-Mediated Drug-Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

N Fermier, L Bourguignon, S Goutelle… - Clinical …, 2018 - pubmed.ncbi.nlm.nih.gov
Background and objective The magnitude of drug-drug interactions mediated by cytochrome
P450 (CYP) may depend on the genotype of polymorphic cytochromes. The objective of this …

Identification of Cytochrome P450-Mediated Drug–Drug Interactions at Risk in Cases of Gene Polymorphisms by Using a Quantitative Prediction Model

N Fermier, L Bourguignon, S Goutelle… - Clinical …, 2018 - search.proquest.com
Abstract Background and Objective The magnitude of drug–drug interactions mediated by
cytochrome P450 (CYP) may depend on the genotype of polymorphic cytochromes. The …