[HTML][HTML] Anakinra in COVID-19: important considerations for clinical trials

A King, A Vail, C O'Leary, C Hannan… - The Lancet …, 2020 - ncbi.nlm.nih.gov
… observed in patients with COVID-19.1, 3 At the time of writing, there are ten ongoing clinical
trials in COVID-19 with the drug anakinra (table ). Anakinra inhibits the proinflammatory …

Efficacy and safety of anakinra plus standard of care for patients with severe COVID-19: a randomized phase 2/3 clinical trial

P Fanlo, B del Carmelo Gracia-Tello… - JAMA Network …, 2023 - jamanetwork.com
… Meaning This study did not find evidence of effectiveness of anakinra vs the standard of …
with severe COVID-19 pneumonia, and future research should assess anakinra in patients with …

Effect of anakinra in COVID-19

EJ Kooistra, NJB Waalders, M Kox… - The Lancet …, 2020 - thelancet.com
… (suppression of C-reactive protein or fever) as important considerations. The use of … deci
sion making at the cusp of the COVID-19 pandemic. Several ongoing clinical trials will follow …

Anakinra for severe forms of COVID-19: a cohort study

T Huet, H Beaussier, O Voisin… - The Lancet …, 2020 - thelancet.com
… with COVID-19. We aimed to assess the off-label use of anakinra in patients who were
admitted to hospital for severe forms of … A real-time dashboard of clinical trials for COVID-19. …

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

EJ Kooistra, NJB Waalders, I Grondman, NAF Janssen… - Critical care, 2020 - Springer
… In the present study, the effects of anakinra in critically ill COVID-19 patients with clinical
These issues might have confounded the clinical outcome results demonstrated in these …

Current evidence on the use of anakinra in COVID-19

E Khani, M Shahrabi, H Rezaei, F Pourkarim… - International …, 2022 - Elsevier
… or completed clinical trials on the use of anakinra in COVID-19 … Overall, 6 ongoing trials
were registered in the clinicaltrials.gov … Anakinra did not result in any critical safety issues when …

A randomized controlled clinical trial on efficacy and safety of anakinra in patients with severe COVID19

AB Kharazmi, O Moradi, M Haghighi… - Immunity …, 2022 - Wiley Online Library
anakinra may improve the patient's situation, and in this study, we … efficacy of anakinra in
patients diagnosed with COVID-19. … As an important consideration to our study, we administered …

Anakinra for the treatment of COVID-19 patients: a systematic review and meta-analysis

K Dahms, A Mikolajewska, K Ansems… - … of medical research, 2023 - Springer
… However, the role of Anakinra in COVID-19 remains unanswered, especially in patients …
and effects of Anakinra compared to placebo or standard care alone on clinical outcomes in …

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

E Kyriazopoulou, T Huet, G Cavalli, A Gori… - The Lancet …, 2021 - thelancet.com
… or laboratory signs of hyperinflammation, or both, or in the context of clinical trials, in an …
an important role in COVID-19 pathophysiology. We aimed to investigate the effect of anakinra

… tocilizumab, sarilumab, and anakinra for critically ill patients with COVID-19 the REMAP-CAP COVID-19 immune modulation therapy domain randomized clinical trial

REMAP-CAP Investigators, LPG Derde, AC Gordon… - MedRxiv, 2021 - medrxiv.org
… not observe a beneficial effect of anakinra in critically ill patients with COVID-19. Previous
studies and a recent meta-analysis provided a rationale for the use of anakinra in COVID-19. …