Approved antiviral drugs over the past 50 years

E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
… of the following 9 human infectious diseases: (i) HIV infections (protease … of antiviral
drugs approved over the past 50 years, shedding light on the development of effective antiviral

Looking back in 2009 at the dawning of antiviral therapy now 50 years ago: an historical perspective

E De Clercq - Advances in Virus Research, 2009 - Elsevier
… those 50, exactly 25 have been formally approved as anti-HIV … small-molecular-weight antiviral
drug to be licensed for clinical … Now 50 years after this report appeared, we have about 50

A decade of FDA-approved drugs (2010–2019): trends and future directions

DG Brown, HJ Wobst - Journal of medicinal chemistry, 2021 - ACS Publications
… By far the largest impact in antiviral drug discovery in the past decade was in hepatitis C …
on year of approval (Figure 16). We found that on average 37% of new drugs over the past

The history of antiretrovirals: key discoveries over the past 25 years

E De Clercq - Reviews in medical virology, 2009 - Wiley Online Library
Within 25 years after zidovudine (3 … described as an inhibitor of HIV replication, 25 anti-HIV
drugs have been formally … Anti-HIV drugs: 25 compounds approved within 25 years after the …

Fifty years in search of selective antiviral drugs: miniperspective

E De Clercq - Journal of medicinal chemistry, 2019 - ACS Publications
… The fourth NRTI ever approved by the US FDA as an anti-HIV drug, 2′,3′-dideoxy-2′,3′…
It would gain wide acceptance all over the world as an anti-HIV drug until it was superseded …

Antivirals: past, present and future

E De Clercq - Biochemical pharmacology, 2013 - Elsevier
antiviral drug to be used in the topical treatment of herpetic eye infections. IDU was not the
first antiviral … ® is the first and only antiviral drug approved for the prevention of HIV infections. …

[HTML][HTML] History and progress of antiviral drugs: From acyclovir to direct-acting antiviral agents (DAAs) for Hepatitis C

OL Bryan-Marrugo, J Ramos-Jiménez… - Medicina …, 2015 - Elsevier
antiviral drugs is a very complex process. Currently, around 50 drugs have been approved
… the development of antiviral drugs over the next 20 years will be focused on HIV and HCV. …

[HTML][HTML] Approved HIV reverse transcriptase inhibitors in the past decade

G Li, Y Wang, E De Clercq - Acta Pharmaceutica Sinica B, 2022 - Elsevier
… active antiretroviral therapies (HAARTs) for anti-HIV treatmentapproved in the past ten
years, but a review on their drug … ) approved in the past decade, regarding their drug discovery, …

Antiviral therapy: old and current issues

G Antonelli, O Turriziani - International journal of antimicrobial agents, 2012 - Elsevier
… Today around 50 antiviral drugs have been approved for the … During the past 50 years a
number of antiviral drugs have … , during the last decade the choice of antiretroviral drugs has …

Recent highlights in the development of new antiviral drugs

E De Clercq - Current opinion in microbiology, 2005 - Elsevier
… on the development of improved antiviral therapies for virus … to antiviral drug treatment, as
well as for virus infections for which, at present, no antiviral drugs have been formally approved