[HTML][HTML] Drug repurposing approaches to combating viral infections

J Trivedi, M Mohan, SN Byrareddy - Journal of clinical medicine, 2020 - mdpi.com
… block HIV replication in vitro [32], and soon after this study was published AZT received the
approval from … Since the approval of the first anti-HIV medicine, the development of novel anti-…

A survey of the structures of US FDA approved combination drugs

P Das, MD Delost, MH Qureshi, DT Smith… - Journal of medicinal …, 2018 - ACS Publications
… The most recent approved drug included in our survey, Delstrigo … fumarate), was approved
in 2018 to treat HIV-1 infection for adults… antiviral drug classes, seen in combinations for HIV-1 …

The history of antiretroviral therapy and of its implementation in resource-limited areas of the world

S Vella, B Schwartländer, SP Sow, SP Eholie… - Aids, 2012 - journals.lww.com
… was approved in 1987 for use in patients with advanced HIV. In short succession, three other
NRTIs were approved for use in HIV… in antiretroviral drug development in the coming years (…

The use of antiviral drugs for influenza: guidance for practitioners 2012/2013

FY Aoki, UD Allen, HG Stiver… - Canadian Journal of …, 2012 - Wiley Online Library
… Please note that antivirals are not authorized for the routine treatment of seasonal influenza
illness in infants younger than 1 year of age. Such use may be considered on a case-by-…

[PDF][PDF] Antiviral drug‐resistant HBV: standardization of nomenclature and assays and recommendations for management

AS Lok, F Zoulim, S Locarnini, A Bartholomeusz… - …, 2007 - Wiley Online Library
… been made in the treatment of chronic hepatitis B in the past decade. Approved treatments
for … Sustained viral suppression is rarely achieved after withdrawal of a 48-week course of NA …

The evolution of antiviral therapy for external ocular viral infections over twenty-five years

YJ Gordon - Cornea, 2000 - journals.lww.com
… By 1975, the antiviral treatment of live virus replication associated … 2) are other FDA-approved
antiviral agents that are effective … After 25 years of antiviral development, we currently have …

[HTML][HTML] A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

M Kumari, RM Lu, MC Li, JL Huang, FF Hsu… - Journal of biomedical …, 2022 - Springer
… Despite the options in vaccine design, the development of a vaccine usually takes many
years to progress from the initial design stage to approval and clinical application. Moreover, …

[HTML][HTML] Investigational antiretroviral drugs: what is coming down the pipeline

RM Gulick - Topics in Antiviral Medicine, 2018 - ncbi.nlm.nih.gov
approved drugs, the pipeline of investigational HIV drugs remains full. Investigational
antiretroviral drugs … is active in vitro against NNRTI-resistant HIV and was potent and well–tolerated …

[HTML][HTML] Drug combination therapy for emerging viral diseases

ZA Shyr, YS Cheng, DC Lo, W Zheng - Drug discovery today, 2021 - Elsevier
… repurposing screenings can be performed quickly by using approved drug compound … The
first antiretroviral for HIV treatment, azidothymidine, was approved in 1987. Azidothymidine, a …

Trends in antimicrobial drug development: implications for the future

B Spellberg, JH Powers, EP Brass… - Clinical infectious …, 2004 - academic.oup.com
… Food and Drug Administration (FDA) databases of approved drugs and the … Antiviral
medications were considered separately because factors in the decisions to develop HIV drugs are …