… FTO-mediated mRNA demethylation … FTO-induced oncogenic effects on the proliferation
and invasion of OS cells. Overall, our findings showed that FTO-mediated m6A modification of …

… DNA modifications, histone modifications and RNA-mediated … FTO-mediated m 6 A
demethylation regulates adipose tissue … expression of downstream targets Kruppel-like factor 4 …

… FTO (fat mass and obesity-associated protein) abolished the atorvastatin-mediated induction
of KLF2 (Kruppel-like … eNOS as targets of FTO mediating m6A modification, we performed …

… Fto is permissive for adipogenesis and promotes maintenance of … of fat mass in mice
segregating for a dominant-negative Fto … of the human fat mass and obesity associated FTO gene. …

… 1; YTHDF, YTH N6-methyladenosine RNA binding protein; … ALKBH5 upregulation mediates
NANOG expression and … I367F) in the Fto gene resulted in reduced fat mass, increased …

… of adipose tissues, and play a pivotal role in multiple rounds of MCE (Figure 2). [ 49 ] Another
class of factors, namely, the kruppel-like … FTO and FTO-mediated low m 6 A modification act …

… M6A is a reversible RNA modification in eukaryotes that can … smooth muscle cells by
increasing Krüppel-like factor 5 (Klf5) … that FLOT2 loss abrogated FTO-mediated pro-proliferative …

… migration, whereas knockdown of FTO inhibits these functions. Mechanically, we identified
Krüppel-like factor 5 (Klf5) as a target of FTO mediating m6A modification. Overexpression of …

… In addition, fat mass and obesity-associated protein (FTO) … 4A), while Krüppel-like factor 15
is associated with obesity [45], … -mediated RNA silencing controls energy metabolism linked …

… of N6-methyladenosine (m 6 A) mRNA modification, is … on thermogenic mRNAs, including
Krüppel-like factor 9 (Klf9), … for fat storage, whereas beige and brown adipocytes mediate …