… , the underlying molecular mechanisms of their extended healthspans are poorly understood.
To address this question we carried out an eight-year longitudinal study of ageing in long-…

… , and it is leveraging unique and very large human study … , healthy long-lived individuals,
longitudinal and pedigree data … with human longevity and health span. These variants will also …

… We propose that comparative immunogenomics offers a solution to the problem of estimating
past selection on immune genes. Specifically, long-read sequencing (LRseq) technology …

… 4: Transcriptomic analyses of HPB reveal unique pathway … Therefore, we believe that
extensions of healthspan and … has yet to be demonstrated using a longitudinal model. It is critical …

… calorie restriction to increase health span and extend mouse longevity. PLoS One. 2013;8:e53760. …
The role of longitudinal cohort studies in epigenetic epidemiology: challenges and …

… Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic …
healthspan, lifespan, and exceptional longevity (multivariate longevity). Using transcriptomic …

… Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
… Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. …

… comparison of age-related transcriptomic changes in Myotis, human, mouse and wolf. Myotis
exhibits unique molecular mechanisms for lifespan extension … obtained transcriptome data …

… of long-lived species would help to reveal pro-longevity genetic programs. Transcriptomic
analysis of exceptionally long-… that might potentially support their long lifespan. In a milestone …

… axis has long been investigated in the context of healthspan and lifespan extension, dating
… expression and metabolome changes in a longitudinal way. Such studies should include …