… Using the recently determined structure of the classical MHC-I molecule, H-2Dd, as a
paradigm for structure and function, we review other MHC-I and MHC-Ib molecules, with an …

… cellular transport until the class II molecules are introduced into the … MHC class II function
are discussed in detail after an initial description of the structural features of these molecules…

… in every case their function is … structure of these diverse nonclassical and MHC class I–like
proteins; owing to space constraints, discussion centers on molecules that have had structural …

… Introduction The functions of MHC class II molecules include the … and MHC class II incompatible
graft rejection; (v) transmembrane signalling, contributing to the activation of MHC class II…

… To avoid killing by NK cells in utero, these cells instead express some variant (“nonclassical”)
HLA class I molecules called HLA-G, which function as NK cell inhibitory ligands on …

… structures of MHC class I and class II molecules are now well established. Over the past
twelve months structural data on MHC class I molecules … Recent MHC class II structures have …

… (MHC) molecules are rapidly … The role of the MHC class I molecules, HLA-A, HLA-B and
HLA-C in man, in immunological recognition is well understood both in functional and structural …

… High-affinity binding of short peptides to major histocompatibility complex class II
molecules by anchor combinations. Proc Natl Acad Sci US A. 1994;91(10):4456-60. ) …

… protease resistant, as are MHC class I and class II molecules themselves. However, when
reduced and denatured, resulting in a disordered structure, these proteins become highly …

… for MHC class I molecules, as well asthe genes encoding DM, have since been mapped
to the class II region in bothhuman and mouse (11). The majority ofthe human and mouse …