… important to establish the cellular factors responsible for the different cell-type specific response
to methylglyoxal injury… increasing the intracellular level of methylglyoxal. To this purpose, …

… pathways, the glyoxalase system is the most important as the major detoxifying … also damage
the ability of insulin to bind or activate its receptor and probably lead to insulin resistance[35…

… by interacting with AGEs that damage cells, leading to target … via the kidneys, which are
essential organs for AGE filtration [… with NAC, an ROS scavenger. This suggests that GA and GA-…

… or glyoxal and unsaturated carbonyls such as hydroxynonenal or acrolein have been
suggested as neurotoxic mediators of oxidative damage in the progression of AD and other …

… the scavenging of ROS as well as of the reactive 2-oxoaldehydes … oxidation is fundamental
to block further damage on protein … is important for ROS-mediated signaling pathways. …

… Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal
injury… Methylglyoxal induces oxidative stress-dependent cell injury and upregulation of …

… Oxidative stress is believed to be a very important factor in … Specific and effective scavengers
and crosslink breakers of … and further damage. Ultimately, there is modification of DNA, …

… are mainly produced by ROS-mediated lipid peroxidation, … glyoxalase I-II system also have
important contributions to plant … assessing abiotic stress responses and resistance in plants. …

… by ROS mediated mitochondrial release of cytochrome c. … an important role in the MG induced
apoptosis of MDA MB 231 … Aggressive growth, evasion of apoptotic control, resistance to …

… intermediates of glycolysis induce damage to the vasculature and … itself induce insulin
resistance and β-cell dysfunction, and … Because GSH is also an essential cellular cofactor for Glo1 …