Transcriptomic analysis of autistic brain reveals convergent molecular pathology

I Voineagu, X Wang, P Johnston, JK Lowe, Y Tian… - Nature, 2011 - nature.com
molecular pathways in the brain 4 . Here, we demonstrate consistent differences … transcriptome
organization between autistic and normal brain by gene co-expression network analysis. …

Integrated analysis of brain transcriptome reveals convergent molecular pathways in autism spectrum disorder

X Li, Y Zhang, L Wang, Y Lin, Z Gao, X Zhan… - Frontiers in …, 2019 - frontiersin.org
… In this study, based on protein–protein interactions, post-mortem transcriptome analysis
was performed with corpus callosum (CC) and prefrontal cortex (PFC) samples from ASD …

Autism spectrum disorder: insights into convergent mechanisms from transcriptomics

M Quesnel-Vallières, RJ Weatheritt, SP Cordes… - Nature Reviews …, 2019 - nature.com
… the importance of identifying convergent pathways and molecular mechanisms that are …
transcriptomic analyses have transformed our understanding of pathway convergence in …

Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies

A Gokoolparsadh, GJ Sutton, A Charamko… - Cellular and molecular …, 2016 - Springer
… To investigate transcriptome changes in ASD brain, we carried out the first well-powered
transcriptome study of postmortem brain tissue, using microarray analysis of frontal cortex, …

Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

G Ramaswami, H Won, MJ Gandal, J Haney… - Nature …, 2020 - nature.com
… and control brains to identify a convergent molecular subtype of ASD with shared dysregulation
across both the epigenome and transcriptome. Focusing on this convergent subtype, we …

Cell-type-specific analysis of molecular pathology in autism identifies common genes and pathways affected across neocortical regions

D Velmeshev, M Magistri, EMC Mazza, P Lally… - Molecular …, 2020 - Springer
autism overlap genes associated with development and enriched in human cortical
oligodendrocytes. Our study identifies signatures of autism molecular pathology … of autism

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

J Forés-Martos, F Catalá-López, J Sánchez-Valle… - Molecular autism, 2019 - Springer
… manifestations of autism [28]. The main goal of this study is to identify molecular mechanistic
… With this aim, we conducted meta-analyses of differential RNA expression of ASD brain

Convergent pathways in idiopathic autism revealed by time course transcriptomic analysis of patient-derived neurons

BA DeRosa, J El Hokayem, E Artimovich… - Scientific reports, 2018 - nature.com
… , functional analysis revealed defects in neuronal migration and electrophysiological
activity, providing compelling support for the transcriptome analysis data. This study reveals

Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders

C Brandenburg, AJ Griswold, DJ Van Booven… - Frontiers in …, 2022 - frontiersin.org
… Notably, RELN, as well as multiple ADAMTS and semaphorin genes were differentially
expressed in ASD compared to neurotypical individuals in our PC transcriptome analysis. …

[HTML][HTML] Neural transcriptomic analysis of sex differences in autism spectrum disorder: current insights and future directions

LT Kissel, DM Werling - Biological Psychiatry, 2022 - Elsevier
… summarize convergent findings from several landmark studies of the transcriptome in ASD
brain … and remaining questions regarding transcriptomic analysis of sex differences in ASD. …