A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain poorly defined. To bridge this gap, we generate
maps of long-range chromatin interactions centered on 18,943 well-annotated promoters for
protein-coding genes in 27 human cell/tissue types. We use this information to infer the
target genes of 70,329 candidate regulatory elements and suggest potential regulatory
function for 27,325 noncoding sequence variants associated with 2,117 physiological traits …

A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain to be defined. To bridge this gap, we generate
maps of long-range chromatin interactions centered on 18,943 wellannotated promoters for
protein-coding genes in 27 human cell/tissue types. We use this information to infer the
target genes of 70,329 candidate regulatory elements, and suggest potential regulatory
function for 27,325 non-coding sequence variants associated with 2,117 physiological traits …