Background & Aims: Gut graft-versus-host disease (GVHD) contributes significantly to
lethality after allogeneic hematopoietic stem-cell transplantation (HSCT). In murine models,
macrophage secretion of interleukin 1α (IL-1α) and tumor necrosis factor α (TNF-α)
contributes to gut GVHD pathogenesis. To help characterize whether human gut GVHD has
similar biological characteristics, monocyte IL-1α and TNF-α production were evaluated after
HSCT. Methods: Patients with refractory hematologic malignancy (n= 17) underwent …

Clinical "cytokine storm" as revealed by monocyte intracellular flow cytometry : correlation of
tumor necrosis factor alpha with severe gut graft-versus-host disease | CiNii Research …
Clinical "cytokine storm" as revealed by monocyte intracellular flow cytometry : correlation of
tumor necrosis factor alpha with severe gut graft-versus-host disease …