… biomarkers to identify tractable targets in humans. While it is tempting to postulate that adult
… homeostasis, lipid metabolism, and epigenetic signatures are under intense scrutiny and …

… with significant memory decline and cognitive impairment. AD is … the central focus for the
development of biomarkers and disease-… adult mice by targeting a signaling-directed epigenetic …

… , genetic risk profiles, epigenetic and environmental modifiers. … The addition of quantitative
biomarker panels to clinical … , even though the majority of motor and cognitive functions are …

… (e) Can we identify in elderly individuals epigenetic biomarkers of … Epigenetic modifications
leading to impaired neuronal … of neurodegeneration, in order to identify older adult subjects …

… Dementia is a progressive cognitive impairment that affects … The vast majority of AD occurs
on a seemingly sporadic basis… been shown to be a biomarker candidate in other diseases too. …

… children and much older adults. An estimated 2.5 million … , and cerebrospinal fluid are altered
in multiple sclerosis and can … technology, development of sensitive biomarker assays and …

… repressed in adulthood. Notably, there is evidence indicating that HOX gene expression in
… Secondly, scrutinizing epigenetic changes in AD can shed light on potential biomarkers for …

… that principally affects older adults. Pathogenic factors, such as … in the discovery of epigenetic
biomarkers and in the use of … neuroprotective activity against cognitive impairment, and one …

… migration and impaired dendrite development of adult-born … brain development to establish
cognitive abilities and … epigenetic regulation on the adult hippocampal neurogenesis after …

… , potential candidate biomarkers for schizophrenia in adults could … life can induce through
epigenetic mechanisms changes in … same direction of altered expression and these were then …