… blood-brain barrier permeability in health and disease are … suppressed by treatment with
the mTOR inhibitor Torin-2. The … Inhibition of mTOR protects the blood-brain barrier in models …

… of blood-brain barrier that correlates with Alzheimer’s disease astrocyte. Finally, we evaluate
the roles of soluble factors secreted by Alzheimer’s disease … Pharmacological inhibition on …

… The blood-brain barrier is the interface through which the brain interacts with the milieu and
… It was demonstrated that Gap27 inhibited reactive gliosis in an inflammation model based …

… Autophagy inhibition with the activation of mTOR is sometimes necessary to protect
neurons … exacerbates disruption of the blood-brain barrier following cerebral ischemia-reperfusion …

… )/Akt/mTOR signaling pathway; decreased the phosphorylation levels of inhibitor of NFκB (…
/NFκB signaling pathway; reduced blood-brain barrier permeability and neuronal apoptosis in …

… and highly selective semipermeable border, the blood-brain barrier (BBB). Initial experiments
… , inhibition of the mTOR pathway prolongs the lifetime of various organisms and protects …

… to cross the blood-brain barrier and their unintended side … O-GlcNAc removal inhibition,
and tau acetylation inhibition are … Rapamycin, an mTOR kinase inhibitor is tested in phase 1 …

… potently protects animals in a number of disease models, … not cross the intact blood-brain
barrier. We developed adeno-… may involve Beclin-1, mTOR, Wnt, and Notch pathways (shown …

… neurological disorders: Our recent study showed that combined inhibition of two Src family
… that administration of imatinib restored the bloodbrain barrier, reduced inflammation, and …

… mTOR signaling components are endogenous inhibitory … To specifically tackle the blood-brain
barrier issue, we will … a very stable structure to protect nucleic acids from degradation, but …