… novel scaffolds, including 2 compounds from chemical synthesis and 3 natural products,
including … important information for new drug design. Based on the studies above, more than 20 …

… Strategies for the development of drugs targeting novel … Network pharmacology: the next
paradigm in drug discovery [J]. … Structure of SARS coronavirus spike receptor-binding domain …

… Drug development from naturally-sourced pharmacological … The recent outbreak of the novel
coronavirus (COVID-19) … agents on the spike glycoprotein of SARSCoV-2. Saudi J Biol Sci. …

… 首先在M06-2X/6-31G (d)理论计算水平下对如表1所示的7种SARS-CoV-2抑制剂的初始结构
进行几何优化,获得稳定分子构型.随后,在M06-2X/6-311 + G (d, p)水平下计算了7种药物分子的…

… preliminary study in drug discovery (Meng et al., 2011). Another … approaches to estimate
solubility and permeability in drug … and accuracy of docking with a new scoring function, efficient …

… New approaches to drug discovery for COVID-19 treatment … proteins in the process of
SARS-CoV-2 adsorption, entry into … can provide strategies to promote the discovery of drugs with …

… no specific drug or vaccine for the treatment of this kind of virus … recent years and reviews
the medicinal chemistry strategies of anti-SARS-CoV, MERS-CoV and other coronavirus drugs …

… , we propose novel potential strategies for COVID-19 diagnosis and anti-virus drug
development, which provides new directions for the diagnosis and treatment of COVID-19. …

… emergence of drug resistance, toxicity and superinfection have posed new challenges for
nucleoside-based antiviral drug discovery. Many research found that chemical manipulation …

… progress on both approaches. Here we review potential anti-SARS-CoV-2 drugs to discuss
the antiviral mechanisms and potential of these drugs from the perspectives of virus and host. …