[HTML][HTML] Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our
investigation. Using 25 GWAS results and LD score regression, we find eight significant
genetic correlations between psychiatric and neurodegenerative diseases. We integrate the
GWAS results with human brain transcriptomes (n= 888) and proteomes (n= 722) to identify
cis-and trans-transcripts and proteins that are consistent with a pleiotropic or causal role in …
however, whether they share pathophysiology is unclear and is the focus of our
investigation. Using 25 GWAS results and LD score regression, we find eight significant
genetic correlations between psychiatric and neurodegenerative diseases. We integrate the
GWAS results with human brain transcriptomes (n= 888) and proteomes (n= 722) to identify
cis-and trans-transcripts and proteins that are consistent with a pleiotropic or causal role in …
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