… covering five major psychiatric disorders and compared cases … psychiatric disorders share
global gene expression patterns. This overlap in polygenic traits in neuropsychiatric disorders …

… identifying genetic risk factors for major psychiatric disorders, it remains unknown how …
disorders (1, 2). We reasoned that brain transcriptomes—a quantitative, genome-wide molecular …

… with power that hinder identification, efforts have focused on polygenic attempts to determine
shared risk. The methods covered below to estimate overlap in genetic loading include …

… whether overlapping transcriptome patterns across disorders are related to shared genetic
aetiologies, as measured by SNP-based polygenic correlation from a recent cross disorder …

… overlap beyond r g , we provide insights into the unique and shared genetic architectures
underlying psychiatric disorders, with … ” genetic overlap observed across all polygenic traits, or, …

… disease causal proteins are shared with psychiatric disorders… full range of cognitive and
neuropathologic disease severity. … was aliquoted and digested in parallel to make up the global …

… genomic studies regarding pleiotropy and the shared genetic basis of psychiatric disorders.
… across all causal loci (7). In this article, we use r g as an index of polygenic overlap between …

… now overwhelming that psychiatric disorders are ‘‘polygenic’’… of different psychiatric disorders
often strongly overlap, we … inherited liability are shared by many psychiatric disorders. But …

… functional MRI activity and polygenic risk for SCZ and BD [26… of a significant overlap in
sMRI phenotypes along with the … neurological and psychiatric disorders as reported by [2]. …

… There is widespread overlap across major psychiatric disorders, and this is the case at …
more aligned with the shared genetic underpinnings among psychiatric conditions. This could …