… barrier leakage to neurodegeneration and cognitive decline in AD. Finally, we discuss clinical
relevance … on investigating barrier leakage in AD. Identifying mechanistic steps underlying …

… Thus, although this represents an acute disease model, the mechanisms are relevant to
graft… and epithelial barrier dysfunction. The barrier loss results in greater access leakage of …

… of clinical recommendation. We wanted to explore the patterns of ‘leakage’ and summarise
any identified barriers … were chosen post-hoc, to reflect clinically related and relevant themes. …

… of the microvascular barrier. Derangements in microvascular barrier function limit tissue …
, demonstrating the complexity of microvascular barrier regulation. Understanding these …

… Although cSVD is the clinical focus of this work, we have referred to technically relevant …
for obtaining BBB leakage measurements in future clinical studies of cSVD and dementia as …

… which are stricter and more reliable than standard clinical criteria. In conclusion, in this pilot
… relevant relationships. MJPvO Activities related to the present article: disclosed no relevant …

… ie, with beginning CSF outflow, which contradicts a relevant outflow to the lymphatic system.
… clinical data, to substantiate this fundamental change in the concept of the biological barrier …

… , possibly implying a greater clinical relevance of BBB disruption in … Analysis of clinically
relevant subgroups might have … because it has limited clinical relevance for decision making and …

… of barrier loss with disease reactivation (104), suggested that tight junction dysregulation
might be of great clinical relevance. More recently, the association of tight junction barrier loss …

… barrier. In contrast, barrier breakdown is required for leakage of plasma macromolecules.
Details of the processes involved in leukocyte extravasation are available in excellent reviews [ …