… Nafamostat is another TMPRSS2 inhibitor that in a mouse model of COVID-19 reduced SARS-CoV-2 pulmonary infection [17]. A neutralizing antibody directed against the viral S protein …
… of different components of the PI3K/Akt/mTOR pathway did not show the same significant … as therapeutic targets in COVID-19, using the inhibitor SF2523 (a small molecule inhibitor that …
G Ragia, VG Manolopoulos - European journal of clinical pharmacology, 2020 - Springer
… COVID-19 test result. Another TMPRSS2 inhibitor with therapeutic potential for treatment of COVID-19 is … drug for indications unrelated to coronavirus and used in Asian countries as a …
… , which have been shown to inhibit PI3K/AKT signaling pathway and ultimately suppress inflammation [10], along with antiviral drugs to combat COVID-19 can be considered. …
A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
… result in a reduction in the cytokine storm and alleviate the severity of COVID-19. Inhibition of NF-κB pathway has a potential therapeutic role in alleviating the severe form of COVID-19. …
… other potential JAKinibs and novel anti-inflammatory combination therapies that affect the JAK-STAT pathway in patients with COVID-19. Since the combination of MTX and baricitinib …
JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
… , and DHA/EPA, pasireotide), as well as inhibitors targeted toward molecular mediators of the maladaptive COVID-19 immune response (eg, IL-6, TNF-α, IL-17, JAK, and CDK9). …
JM Grimes, KV Grimes - Journal of molecular and cellular cardiology, 2020 - Elsevier
… downregulating a key inhibitorypathway, while simultaneously taking advantage of p38 activity to replicate. Therapeuticinhibition of p38 could therefore attenuate COVID-19 infection. …
… with the mortality of COVID-19 patients. Both the … treatment available for COVID-19, but scientists have purposed several treatment options including cytokine inhibitors, JAK inhibitors…