联用多步骤虚拟筛选方法发现具有新母核的GABAA 受体正性变构调节剂
K Weikaixin, L Jingjing, P Chao, Z Jie, Z Yulin… - 物理化学 …, 2023 - whxb.pku.edu.cn
GABA A 受体主要介导哺乳动物中枢神经系统的抑制性信号传递, 是镇静催眠药的关键靶点.
在寻找具有新母核的镇静催眠药的过程中, 计算机辅助药物设计(CADD) 方法显示出巨大的优势 …
在寻找具有新母核的镇静催眠药的过程中, 计算机辅助药物设计(CADD) 方法显示出巨大的优势 …
[PDF][PDF] Identification of Novel GABAA Receptor Positive Allosteric Modulators with Novel Scaffolds via Multistep Virtual Screening
W Kong, J Lian, C Peng, J Zhu, Y Zheng… - Acta Physico-chimica …, 2024 - whxb.pku.edu.cn
The GABAA receptor mainly mediates inhibitory signal transmission in mammalian central
nervous systems and is the key target of sedative-hypnotics. However, the long-term use of …
nervous systems and is the key target of sedative-hypnotics. However, the long-term use of …
Establishment of a High Throughput Screening System for GABAA1 Modulators in Living Cells
Y Zhang, T Shi, X Chen, R Zhang, J Shi… - … Chemistry & High …, 2023 - ingentaconnect.com
Background: The incidence of sleep disorders is more than 27% in the worldwide, and the
development of novel sleep drugs that target GABAA receptors is of great interest …
development of novel sleep drugs that target GABAA receptors is of great interest …
Integrated workflow for the identification of new GABAAR positive allosteric modulators based on the in silico screening with further in vitro validation. Case study …
M Platonov, O Maximyuk, A Rayevsky… - Molecular …, 2024 - Wiley Online Library
Numerous studies reported an association between GABAAR subunit genes and epilepsy,
eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar …
eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar …
Improving and utilizing functional in vitro cAMP assay in pursuit to discover allosteric modulators of the GABAB receptor
T Pettersen - 2021 - munin.uit.no
The GABAergic system is the main inhibitory neuronal system utilized within the central
nervous system (CNS). γ-aminobutyric acid (GABA) is the fundamental neurotransmitter …
nervous system (CNS). γ-aminobutyric acid (GABA) is the fundamental neurotransmitter …
Discovery of new scaffolds for GABA (A) receptor modulators from natural origin
JM Zaugg - 2011 - edoc.unibas.ch
Gamma-aminobutyric acid type A (GABAA) receptors are the major inhibitory
neurotransmitter receptors in the central nervous system (CNS). These heteropentameric …
neurotransmitter receptors in the central nervous system (CNS). These heteropentameric …
Integrated workflow for the identification of new GABA positive allosteric modulators based on the in silico screening with further in vitro validation. Case study using …
A Rayevsky, M Platonov, O Maximyuk… - Molecular …, 2023 - europepmc.org
Numerous studies reported an association between GABA AR subunit genes and epilepsy,
eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar …
eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar …
Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe
S Sakamoto, K Yamaura, T Numata, F Harada… - ACS Central …, 2019 - ACS Publications
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous
system. The fast inhibitory actions of GABA are mainly mediated by GABAA receptors …
system. The fast inhibitory actions of GABA are mainly mediated by GABAA receptors …
Novel positive allosteric modulators of GABAA receptors with anesthetic activity
MC Maldifassi, R Baur, D Pierce, A Nourmahnad… - Scientific reports, 2016 - nature.com
GABAA receptors are the main inhibitory neurotransmitter receptors in the brain and are
targets for numerous clinically important drugs such as benzodiazepines, anxiolytics and …
targets for numerous clinically important drugs such as benzodiazepines, anxiolytics and …
Identification and characterization of a novel allosteric glutamate binding site on the GABA-A receptor
Y Wen - 2016 - open.library.ubc.ca
The A type γ-aminobutyric acid receptor (GABAAR) mediates major inhibition to counteract
glutamate receptor-mediated excitation in the Central Nervous System (CNS). However …
glutamate receptor-mediated excitation in the Central Nervous System (CNS). However …