[HTML][HTML] Constitutive expression of human telomerase enhances the proliferation potential of human mesenchymal stem cells

DS Bischoff, NS Makhijani, DT Yamaguchi - 2012 - liebertpub.com
Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering
due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of …

Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite of …

BM Abdallah, M Haack-Sørensen, JS Burns… - Biochemical and …, 2005 - Elsevier
Human bone marrow mesenchymal stem cells (hMSC) represent a population of stem cells
that are capable of differentiation into multiple lineages. However, these cells exhibit …

Expression of telomerase extends longevity and enhances differentiation in human adipose tissue-derived stromal cells

ES Jun, TH Lee, HH Cho, SY Suh… - Cellular Physiology and …, 2004 - karger.com
Human bone marrow stromal cells (hBMSCs) are defined as pluripotent progenitor cells with
the ability to differentiate into osteoblasts, chondrochytes, adipocytes, muscle cells, and …

Inducible immortality in hTERT‐human mesenchymal stem cells

SL Piper, M Wang, A Yamamoto… - Journal of …, 2012 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) are attractive candidates for tissue engineering
and cell‐based therapy because of their multipotentiality and availability in adult donors …

Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

JL Simonsen, C Rosada, N Serakinci, J Justesen… - Nature …, 2002 - nature.com
Human bone marrow stromal cells (hMSCs) were stably transduced by a retroviral vector
containing the gene for the catalytic subunit of human telomerase (hTERT). Transduced …

Introducing a single‐cell‐derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer

W Böcker, Z Yin, I Drosse, F Haasters… - Journal of cellular …, 2008 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) can be readily isolated from bone marrow and
differentiate into multiple tissues, making them a promising target for future cell and gene …

Stabilization of cellular properties and differentiation mutilpotential of human mesenchymal stem cells transduced with hTERT gene in a long‐term culture

G Huang, Q Zheng, J Sun, C Guo… - Journal of Cellular …, 2008 - Wiley Online Library
Human bone marrow mesenchymal stem cells (hMSCs) are promising candidates for cell
therapy and tissue engineering. The life span of hMSCs during in vitro culture is limited …

Telomerase deficiency impairs differentiation of mesenchymal stem cells

L Liu, CM DiGirolamo, PAAS Navarro, MA Blasco… - Experimental cell …, 2004 - Elsevier
Expression of telomerase activity presumably is involved in maintaining self-replication and
the undifferentiated state of stem cells. Adult mouse bone marrow mesenchymal stem cells …

Expression of telomerase extends the lifespan and enhances osteogenic differentiation of adipose tissue–derived stromal cells

SK Kang, L Putnam, J Dufour, J Ylostalo, JS Jung… - Stem …, 2004 - academic.oup.com
Expression of TERT, the catalytic protein subunit of the telomerase complex, can be used to
generate cell lines that expand indefinitely and retain multilineage potential. We have …

Neoplastic transformation by TERT in FGF-2-expanded human mesenchymal stem cells

E Yamaoka, E Hiyama… - International …, 2011 - spandidos-publications.com
The low percentage of human mesenchymal stem cells (hMSCs) in bone marrow
necessitates their in vitro expansion prior to clinical use in regenerative medicine. We …