To create immortal mesenchymal cell lines, we transduced primary human bone marrow
mesenchymal cells with telomerase reverse transcriptase (TERT). TERT+ mesenchymal …

Human bone marrow mesenchymal stem cells (hMSC) represent a population of stem cells
that are capable of differentiation into multiple lineages. However, these cells exhibit …

Human bone marrow stromal cells (hMSCs) were stably transduced by a retroviral vector
containing the gene for the catalytic subunit of human telomerase (hTERT). Transduced …

Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering
due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of …

Expression of telomerase activity presumably is involved in maintaining self-replication and
the undifferentiated state of stem cells. Adult mouse bone marrow mesenchymal stem cells …

Loss of telomeric repeats has been causally linked to replicative senescence and aging in
human cells. In contrast to normal somatic cells, which are telomerase‐negative …

Telomerase activity and telomere maintenance have been associated with immortality in
tumor and embryonic stem cells. Whereas most normal somatic cells are telomerase …

Significant improvement in the understanding of mesenchymal stem cell (MSC) biology has
opened the way to their clinical use. However, concerns regarding the possibility that MSCs …

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric repeats onto the
3′ ends of eukaryotic chromosomes. Activation of telomerase may prevent telomeric …

The loss of telomeric DNA may serve as a mitotic clock which signals cell senescence and
exit from cell cycle. Telomerase, an enzyme which synthesizes telomeric repeats de novo, is …