Apolipoprotein E (ApoE), which is genetically polymorphic, is a constituent of different
lipoproteins. Two variants, ApoE4 (C112R) and ApoE4 (L28P; C112R) have been linked to …

The ε4 allele of apolipoprotein E (apoE) is a genetic risk factor for Alzheimer's disease (AD).
In order to gain a better understanding of the molecular mechanisms by which apoE and …

The ε4 allele of apolipoprotein E (apoE) is associated with increased risk for Alzheimer's
disease (AD) and poor outcome after brain injury. In the CNS, apoE is expressed by glia …

Apolipoprotein E (apoE) isoforms are key determinants of susceptibility to late-onset
Alzheimer's disease (AD). The ε4 and ε2 alleles have been associated with increased and …

The ε 4 allele of apolipoprotein E (apoE) is associated with an increased risk of developing
Alzheimer's disease (AD). To accurately determine the isoform-specific effects of human …

Transgenic mice were created using human apolipoprotein E2, E3, and E4 gene fragments
driven by the human glial acidic fibrillary protein (GFAP) promoter. Founders were obtained …

Apolipoprotein E (apoE) and its three major alleles (APOE2, E3, andE4) have been
implicated in Alzheimer's disease and other neurological disorders. Little is known of the …

Abstract Apolipoprotein E4 (apoE4) is a major risk factor for Alzheimer's disease (AD).
Several hypotheses have been proposed to explain the association of the APOE ε4 allele …

Apolipoprotein E polymorphic variants (ApoE-ϵ2, ϵ3, and ϵ4) are associated with the age
of onset distribution and risk of Alzheimer disease. The question of whether ApoE is …

Apolipoprotein E fulfills fundamental functions in lipid transport and neural tissue repair after
injury. 6, 8 Its three most common isoforms (E2, E3, and E4) are critical determinants of …