Telomerase activity has been suggested to be critically involved in hematopoietic stem cell
(HSC) self-renewal. However, it has been unclear whether human HSCs have telomerase …

Telomerase activity has been suggested to be critically involved in hematopoietic stem cell
(HSC) self-renewal. However, it has been unclear whether human HSCs have telomerase …

Strategies for expanding hematopoietic stem cells (HSCs) could have significant utility for
transplantation-based therapies. However, deleterious consequences of such manipulations …

Background: Telomerase, an enzyme complex that adds telomere repeats to the ends of
linear chromosomal DNA, is an important regulator of cellular senescence and replication …

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric repeats onto the
3′ ends of eukaryotic chromosomes. Activation of telomerase may prevent telomeric …

Loss of telomeric repeats has been causally linked to replicative senescence and aging in
human cells. In contrast to normal somatic cells, which are telomerase‐negative …

Telomere shortening ultimately limits the replicative life span of cultured human somatic
cells. Telomeres also shorten during replicative aging in vivo in hematopoietic cells …

Human bone marrow mesenchymal stem cells (hMSCs) are a promising source for clinical
stem cell transplantation. However, telomere regulation mechanisms, as one of the possible …

Studies in murine hematopoiesis have demonstrated that the hematopoietic system is a
hierarchy maintained by rare self-renewing pluripotent hematopoietic stem cells (HSC) …

High-level expansion of hematopoietic stem cells (HSCs) in vitro will have an important
clinical impact in addition to enabling elucidation of their regulation. Recently, it has been …