Diverse individuals age at different rates and display variable susceptibilities to tissue aging,
functional decline and aging-related diseases. Centenarians, exemplifying extreme …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

The identification of plasma proteins that systematically change with age and, independent
of chronological age, predict accelerated decline of health is an expanding area of research …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Background Identifying biological pathways that vary across the age spectrum can provide
insight into fundamental mechanisms that impact disease and frailty in the elderly. Few …

Aging entails gradual functional decline influenced by interconnected factors. Multiple
hallmarks proposed as common and conserved underlying denominators of aging on the …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Discovering the biological basis of aging is one of the greatest remaining challenges for
biomedical field. Work on the biology of aging has discovered a range of interventions and …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …