Neural Regen Res: 研究阿尔茨海默病的体外3D 脑模型阿尔茨海默病是一种进行性的,
不可逆的神经退行性疾病, 可导致认知功能下降, 行为和社会表现恶化. 该病的病因与遗传和环境 …

Cell-based models are a promising tool in deciphering the molecular mechanisms
underlying the pathogenesis of neurological disorders as well as aiding in the discovery and …

The major challenges of the “brain disorders” field–dementia, schizophrenia, other
neuropsychiatric disorders–are that these are defined by clinical phenotypes whose …

Deciphering the human brain pathophysiology remains one of the greatest challenges of the
21st century. Neurological disorders represent a significant proportion of diseases burden; …

The study of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's
disease, Huntington's disease, or amyotrophic lateral sclerosis) is very complex due to the …

Neurodegenerative disorders have an enormous impact on society and healthcare budgets.
There has been a high degree of failure in many recent clinical trials for disease-modifying …

The incidence of Alzheimer's disease is increasing with the aging population, and it has
become one of the main health concerns of modern society. The dissection of the underlying …

Background Neurodegenerative diseases are highly complex making them challenging to
model in cell culture. All cell types of the brain have been implicated as exerting an effect on …

Human-relevant three-dimensional (3D) models of cerebral tissue can be invaluable tools to
boost our understanding of the cellular mechanisms underlying brain pathophysiology …

Until recently, a great amount of brain studies have been conducted in human post mortem
tissues, cell lines and model organisms. These researches provided useful insights …