Telomerase activity has been suggested to be critically involved in hematopoietic stem cell
(HSC) self-renewal. However, it has been unclear whether human HSCs have telomerase …

Strategies for expanding hematopoietic stem cells (HSCs) could have significant utility for
transplantation-based therapies. However, deleterious consequences of such manipulations …

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric repeats onto the
3′ ends of eukaryotic chromosomes. Activation of telomerase may prevent telomeric …

Loss of telomeric repeats has been causally linked to replicative senescence and aging in
human cells. In contrast to normal somatic cells, which are telomerase‐negative …

Telomere shortening ultimately limits the replicative life span of cultured human somatic
cells. Telomeres also shorten during replicative aging in vivo in hematopoietic cells …

Human bone marrow mesenchymal stem cells (hMSCs) are a promising source for clinical
stem cell transplantation. However, telomere regulation mechanisms, as one of the possible …

Low levels of telomerase activity have recently been detected in human primitive
hematopoietic cells, however, blood cells exhibit telomere shortening on cell proliferation …

Telomerase may contribute to the capacity for cell replication by compensating for the loss of
telomere length. Exploring the use of biological modifiers in increasing cellular replicative …

Telomeres shorten in hematopoietic cells, including hematopoietic stem cells (HSCs), during
aging and after transplantation, despite the presence of readily detectable levels of …

Overexpression of telomerase reverse transcriptase (hTERT) can immortalize some primary
human mesenchymal cells. We investigated whether retrovirally-mediated expression of …