Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
JM Murabito, R Yuan, KL Lunetta - Journals of Gerontology …, 2012 - academic.oup.com
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …
the identification of the underlying genes remains a challenge. Longevity is a complex …
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
[HTML][HTML] Human longevity: 25 genetic loci associated in 389,166 UK biobank participants
LC Pilling, CL Kuo, K Sicinski, J Tamosauskaite… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …
Demographics, phenotypic health characteristics and genetic analysis of centenarians in China
After a brief introduction to the background, significance and unique features of the
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …
[HTML][HTML] Historical demography and longevity genetics: back to the future
Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …
number of identified disease-susceptibility loci, it is not known which loci influence …
Polygenic risk score of longevity predicts longer survival across an age continuum
N Tesi, SJ van der Lee, M Hulsman… - The Journals of …, 2021 - academic.oup.com
Studying the genome of centenarians may give insights into the molecular mechanisms
underlying extreme human longevity and the escape of age-related diseases. Here, we set …
underlying extreme human longevity and the escape of age-related diseases. Here, we set …
The quest for genetic determinants of human longevity: challenges and insights
Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …