Background Telomerase deficiency has been associated with inadequate differentiation of
mesenchymal stem cells. However, the effect of telomerase deficiency on differential …

Telomerase activity can prevent telomere shortening and replicative senescence in human
somatic cells. We and others have previously demonstrated that forced expression of …

Long term in vitro expansion of bone marrow stromal (skeletal) stem cells (also known as
human mesenchymal stem cells [hMSC]) is associated with replicative senescence and …

The fate of human hematopoietic stem cells (HSCs)/progenitor cells (HPCs) is influenced by
bone marrow (BM) stromal cells. To investigate the role of stromal cells in the hematopoietic …

Human bone marrow mesenchymal stem cells (hMSCs) are a promising source for clinical
stem cell transplantation. However, telomere regulation mechanisms, as one of the possible …

Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering
due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of …

The contribution of deficient telomerase activity to age-related decline in osteoblast functions
and bone formation is poorly studied. We have previously demonstrated that telomerase …

Human bone marrow mesenchymal stem cells (hMSC) represent a population of stem cells
that are capable of differentiation into multiple lineages. However, these cells exhibit …

Expression of telomerase activity presumably is involved in maintaining self-replication and
the undifferentiated state of stem cells. Adult mouse bone marrow mesenchymal stem cells …

Significant improvement in the understanding of mesenchymal stem cell (MSC) biology has
opened the way to their clinical use. However, concerns regarding the possibility that MSCs …