Aging or senescence is a process in which individuals undergo an exponential decline in
vitality, leading to death. Recent years, much progress on the molecular mechanisms …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Normal human cells will not divide forever in culture. After a defined number of passages,
every culture enters a viable non-dividing state termed senescence. This led to the proposal …

Tanjun Tong (童坦君, 1934–2022)(Fig. 1), was a renowned biochemist in modern China, this
year marks the 90th anniversary of the birth of him. He was elected as a member …

Cellular senescence is a complex and multistep biological process which cells can undergo
in response to different stresses. Referring to a highly stable cell cycle arrest, cellular …

Cellular senescence is recognized as a critical cellular response to prolonged rounds of
replication and environmental stresses. Its defining characteristics are arrested cell-cycle …

The notion that there might be a cellular basis for aging stems from research that began
several decades ago and was proposed to explain the loss of proliferative homeostasis …

During the last 40 years, the study of the biological basis of aging has progressed
tremendously, and it has now become an independent and respectable field of study and …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cellular senescence is viewed as an irreversible cell-cycle arrest mechanism involving a
complexity of biological progressive processes and the acquisition of diverse cellular …