Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …

Aging is the gradual decline of physiological functions and organismal fitness, which leads
to age-dependent fitness loss, diseases and eventually mortality. Understanding the cause …

This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens
of contributions from leading scholars review various theories of aging, and molecular …

The phenomenon of cellular senescence has been known for almost four decades. Yet, until
very recently, the molecular mechanisms that lead to senescence have been poorly …

The aging process has long been a source of fascination, not least because we are all aging
throughout adult life. Several theories have been put forward to explain why we age …

The word senescence is derived from the Latin word “senex”(meaning old). In biology,
senescence is a process by which a cell ages and permanently stops dividing. Senescence …

Our understanding of the molecular mechanisms underlying cellular and organismal aging
and aging-associated pathology has advanced greatly in recent years [1–5]. A body of …

Despite recent advances in molecular biology and genetics, the mysteries that control
human lifespan are yet to be unraveled. Many theories, which fall into two main categories …

In normal tissue, cell division is carefully regulated to maintain the correct proliferative
balance. Abnormal cell division underlies many hypoproliferative and hyperproliferative …