Normal human and rodent cells in culture exhibit a finite life span at the end of which they
exhibit morphological changes and cease proliferating, a process termed cellular …

Cultured cells lose the ability of DNA synthesis, mitosis, and finally the ability of cell
proliferation after they have undergone a finite number of population doublings in vitro …

Aging is the leading predictive factor of many chronic diseases that account for most of the
morbidity and mortality worldwide, ie, neurodegeneration, cardiovascular, pulmonary, renal …

Cellular senescence was historically discovered as a form of cellular ageing of in vitro
cultured cells. It has been under the spotlight following the evidence of oncogene-induced …

Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

Senescence and quiescence are frequently used as interchangeable terms in the literature
unwittingly. Despite the fact that common molecules play role in decision of cell cycle arrest …

Cells can undergo senescence in both pathological and physiological conditions, acquiring
a state of permanent cell cycle arrest that is associated with resistance to apoptosis and …